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兔侧脑室内注射（ｉ．ｃ．ｖ）钙通道阻断剂戊脉安（１００μｇ）引起平均动脉血压（ＭＡＰ）降低。分别ｉ．ｃ．ｖ血管紧张素Ⅱ（ＡⅡ７．５μｇ）、促甲状腺素释放激素（ＴＲＨ５μｇ）和蛙皮素（ＢＢＳ５μｇ）均引起ＭＡＰ升高。预先ｉ．ｃ．ｖ不引起血压变化剂量的戊脉安（７５μｇ），可分别抑制其后ｉ．ｃ．ｖ的ＡⅡ、ＴＲＨ和ＢＢＳ的升压效应。这些结果提示，家兔动脉血压的正常调节活动以及ＡⅡ、ＴＲＨ和ＢＢＳ的中枢升压作用均与脑内Ｃａ￣（２＋）的跨膜内流有关。
Rabbit intracerebroventricular (i.c.v) calcium channel blocker verapamil (100 μg) caused a decrease in mean arterial pressure (MAP). Respectively i. c. Angiotensin Ⅱ (AⅡ7.5μg), thyrotropin releasing hormone (TRH5μg) and bombesin (BBS5μg) caused MAP increase. Pre-i. c. v Verapamil (75 μg), which did not cause a change in blood pressure, inhibited the subsequent i. c. v A Ⅱ, TRH and BBS boost effect. These results suggest that the normal regulation of arterial blood pressure in rabbits and the central hypertensive effect of AII, TRH and BBS are all related to the transmembrane influx of Ca 2+ in the brain.