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目的评价血清高迁移率族蛋白-1(high mobility group box-1,HMGB-1)与急性冠状动脉综合征患者左室射血分数的关系。方法急性冠状动脉综合征患者121例(ACS组)及体检健康者42例(对照组),比较2组血清HMGB-1水平及左室射血分数、左心室舒张期末径、左心室收缩期末径及二尖瓣口血流E/A峰值比。结果 ACS组患者血清HMGB-1水平明显高于对照组(P<0.05);与对照组比较,ACS组左室射血分数及E/A明显降低,而左心室收缩期末径明显增大(P<0.05);血清HMGB-1水平与左室射血分数呈明显负相关(r=-0.299,P<0.01)。结论血清HMGB-1水平可反映急性冠状动脉综合征患者的左室射血分数,有助于评价其心脏收缩功能。
Objective To evaluate the relationship between serum high mobility group box-1 (HMGB-1) and left ventricular ejection fraction in patients with acute coronary syndrome. Methods 121 patients with acute coronary syndrome (ACS group) and 42 healthy subjects (control group) were enrolled in this study. The levels of serum HMGB-1, left ventricular ejection fraction, end diastolic dimension of left ventricular end systolic diameter And mitral valve orifice blood flow E / A peak ratio. Results The level of serum HMGB-1 in ACS group was significantly higher than that in control group (P <0.05). Compared with control group, the left ventricular ejection fraction and E / A in ACS group were significantly decreased <0.05). The level of serum HMGB-1 was negatively correlated with left ventricular ejection fraction (r = -0.299, P <0.01). Conclusion The level of serum HMGB-1 can reflect the left ventricular ejection fraction in patients with acute coronary syndrome, which is helpful to evaluate the cardiac systolic function.