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目的探讨高原地区(海拔3480m)大鼠30%Ⅲ度烧伤后早期肺脏损伤程度以及使用复方红景天对大鼠肺脏损伤的保护作用机制。方法104只Wistar大鼠随机分为实验组、对照组各48只,另取8只作为对照2组,实验组烧伤前大鼠灌胃复方红景天液,对照组灌胃等渗盐水,对照2组大鼠不作处置。分别在伤后3、6、12、24、48、72h各时相点剖腹抽血检测大鼠动脉血气变化,并摘取大鼠肺脏作病理学检查。结果烧伤后3h实验组和对照组大鼠肺脏损伤明显,持续6～24h加重,48h后损伤程度逐渐下降,血气分析亦有类似结果,此过程实验组较对照组损伤轻微。结论复方红景天对大鼠高原严重烧伤后的肺脏损伤有显著保护作用。
OBJECTIVE: To investigate the degree of early lung injury after 30% degree burns in rats in high altitude areas (3480m above sea level) and the protective mechanism of compound Rhodiola rosea on lung injury in rats. Methods One hundred and forty Wistar rats were randomly divided into experimental group and control group with 48 rats in each group. Another 8 rats were used as control group. Rats in pre-burn group were given intragastric administration of Rhodiola Compound Liquid, and the control group was administered with isotonic saline. Rats in group 2 were not treated. The changes of arterial blood gas were measured by cesarean section at 3, 6, 12, 24, 48, and 72 hours after injury. Rat lungs were removed for pathological examination. RESULTS: The lungs in the experimental group and the control group were significantly damaged 3 h after burn and continued to develop for 6-24 h. The degree of damage gradually decreased after 48 h. Similar results were found in the blood gas analysis. The injury was slight in the experimental group compared with the control group. Conclusion Compound Rhodiola rosea has significant protective effect on lung injury after severe burn at high altitude in rats.