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用洛赛克分别与羟氨苄青霉素、四环素、红霉素联合治疗幽门螺旋菌(HP)阳性的十二指肠球部溃疡63例,疗程2周。溃疡愈合率分别为90％(18/20)、70％(14/20)、82.6％(19/23),三组间比较,均无显著性差异(P均>0.05);HP根除率分别为88％(17/20)、55％(11/20)、56％(13/23),羟氨苄青霉素组较其它两组有显著性差异(P<0.05);三天内腹痛缓解率分别为65％(13/20)、85％(17/20)、34.8％(8/23),前两组较红霉素组有显著和非常显著性差异(P<0.05和P<0.01)。在治疗中未发现明显副反应,患者有较好的耐受性。因此,认为洛赛克与抗生素合用是一种治疗十二指肠球部溃疡(DU)的比较简便、高效、安全的方法。选用氨苄青霉素优于四环素和红霉素。
Losec respectively with amoxicillin, tetracycline, erythromycin combined treatment of Helicobacter pylori (HP) 63 cases of duodenal ulcer were treated for 2 weeks. The rates of ulcer healing were 90% (18/20), 70% (14/20) and 82.6% (19/23), respectively. There was no significant difference between the three groups (P> 0.05) (P <0.05). The remission rate of abdominal pain within three days were (88%), 55% (11/20) and 56% (13/23) 65% (13/20), 85% (17/20) and 34.8% (8/23) respectively. The former two groups had significant and very significant difference compared with erythromycin group (P <0.05 and P <0.01). In the treatment of no obvious side effects, patients have better tolerance. Therefore, the combination of Losec and antibiotics is considered as a relatively simple, effective and safe method for the treatment of duodenal ulcer (DU). Ampicillin is better than tetracycline and erythromycin.