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近年来妊娠对癫痫的影响日益引起兴趣.本文作者前瞻性地随访66个癫痫病人共78次妊娠,比较了妊娠前9个月与妊娠期间癫痫发作次数和严重程度的变化,并监测了妊娠期间抗癫痫药物(AED)的血浓度.患者平均年龄26.5岁(16～40岁),平均患病时间为10.6年(1～27年).患全身性癫痫者17人共有22次妊娠,部分性癫痫者49人共有56次妊娠.每隔一个月由神经科和妇产科医生检查一次,预产期前一个月每周一次.与妊娠期间比较,发作增加一次以上为发作频率增加,发作减少一次为发作频率降低.所用的AEDs为卡马西平、苯妥英、丙戊酸钠、扑痫酮、氯硝安定和/或氧异安定药物浓度分析在服药后1小时内进行.结果表明:就所有类型发作而言,妊娠期间和
The impact of pregnancy on epilepsy has drawn increasing interest in recent years.The authors prospectively followed a total of 78 pregnancies in 66 epilepsy patients and compared changes in the number and severity of seizures during the first trimester of pregnancy and during pregnancy and monitored gestational age The mean serum concentration of antiepileptic drugs (AEDs) was 26.5 years (range, 16 to 40 years) with an average duration of 10.6 years (range 1 to 27 years) .There were 17 pregnancies in 17 persons with generalized epilepsy, Epilepsy 49 people a total of 56 pregnancies every other month by the neurology and obstetrics and gynecology physicians check once a month before the expected date of one week compared with during pregnancy increased seizures more than once the frequency of seizures increased attack was reduced once The frequency of seizures decreased with the use of carbamazepine, phenytoin, valproate, valproate, clonazepam, clonazepam and / or oxyisotopic drug concentration analysis within 1 hour after taking the drug.The results showed that: for all types of attacks In terms of during pregnancy and