论文部分内容阅读
药物-血浆蛋白结合的浓度依赖性能产生非线性动力学,使血浆药物浓度随时间的衰减不呈(?)级动力学函数关系;半衰期随剂量增加而缩短;血浆药物浓度及药-时曲线下面积不随剂量增加而相应按比例增加。结合不影响高摄取药物的清除率,但影响低摄取药物的清除率。
Drug-plasma protein concentration-dependent nonlinear kinetics, plasma drug concentration over time did not show (?) Level kinetic function; half-life shortened as the dose increased; plasma drug concentration and drug-time curve The area does not increase with dose accordingly. Binding does not affect the clearance of highly uptake drugs, but affects the clearance of low uptake drugs.