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目的：测定心脏超声造影剂声微显注射液的白蛋白微球浓度和直径。方法：库尔特粒度分析仪小孔直径７０μｍ，小孔电流８００μＡ，增益系数２，操作方式为Ｓｉｐｈｏｎ５００μｌ。精密吸取样品，以９ｇ·Ｌ－１ＮａＣｌ溶液稀释至１００ｍｌ，搅匀后立即测定。结果：测试杯中微球浓度在７．９８×１０４～３９．９０×１０４ｍｌ－１时呈良好的线性关系；浓度测定的ＲＳＤ为０．９１％，直径测定的ＲＳＤ为１．３０％；测定准确度为９９．５％。结论：用库尔特颗粒粒度分析仪测定声微显注射液的白蛋白微球，方法可靠，测定结果准确，与国外文献报道一致
OBJECTIVE: To determine the concentration and diameter of albumin microspheres in cardiac micro-contrast media. Methods: The Coulter Particle Size Analyzer has a pore diameter of 70 μm, a well current of 800 μA, a gain factor of 2, and a mode of operation of 500 μl for Siphon. Precision drawing samples to 9g · L-1NaCl solution diluted to 100ml, stir immediately after the determination. Results: The concentration of microspheres in the test cup showed a good linearity when the concentration of microspheres was in the range of 7.98 × 104 ~ 39.90 × 104ml-1. The RSD of the concentration was 0.91% and the RSD of the diameter was 1.30% The accuracy is 99.5%. Conclusion: Coulter particle size analyzer for the determination of albumin microspheres injection of micro-sound microscopy, reliable, accurate determination of the results, consistent with foreign literature