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目的探讨钙卫蛋白和TNF-α在妊娠期高血压疾病中的表达及其意义。方法采用ELISA法检测60例妊娠期高血压疾病患者及32例正常足月妊娠妇女(对照组)血清中钙卫蛋白和TNF-α水平,采用免疫组化SP法检测各组胎盘组织中钙卫蛋白和TNF-α的表达。结果钙卫蛋白、TNF-α在妊娠期高血压疾病中的表达明显高于对照组,且与病情严重程度呈正相关,钙卫蛋白、TNF-α在妊娠期高血压疾病中的表达呈明显的一致性。结论孕妇血清及胎盘组织中钙卫蛋白、TNF-α水平变化与妊娠期高血压疾病发病及病情发展有关。
Objective To investigate the expression and significance of calprotectin and TNF-α in gestational hypertension. Methods Serum levels of calprotectin and TNF-α in 60 patients with gestational hypertension and 32 normal pregnant women (control group) were measured by ELISA. The levels of calpain and TNF-α were detected by immunohistochemical SP method Protein and TNF-α expression. Results The expressions of calprotectin and TNF-α in gestational hypertension were significantly higher than those in control group, and positively correlated with the severity of the disease. The expressions of calprotectin and TNF-α in gestational hypertension were significantly higher than those in control group consistency. Conclusion The changes of calprotectin and TNF-α levels in serum and placenta of pregnant women are related to the pathogenesis and progression of hypertensive disorder complicating pregnancy.