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目的探讨脑脊液中可溶性白细胞介素2受体水平的变化对脑膜炎的鉴别诊断价值。方法用ELISA法对66例初诊为颅内感染患儿，其中化脓性脑膜炎（化脑）19例，结核性脑膜炎（结脑）20例，病毒性脑膜炎（病脑）27例．进行了脑脊液中可溶性白细胞介素2受体（sIL－2R）水平测定，并与对照组测定值进行比较。结果患儿组的测定位均明显高于对照组测定值．其中以结脑患儿组测定值最高，各患儿组之间的测定值均存在明显差别（P＜0．001）。结脑组和化脑组患儿sIL－2R的测定值存在部分重叠．与病脑组患儿的测定值无任何重叠。结论脑脊液中sIL－2R的测定可能有助于辅助病脑同结脑、化脑的鉴别。
Objective To investigate the differential diagnosis value of cerebrospinal fluid soluble interleukin-2 receptor level in meningitis. Methods Sixty-six cases of newly diagnosed intracranial infection were analyzed by ELISA. Among them, 19 cases were purulent meningitis (TB), 20 cases were tuberculous meningitis (TB) and 27 cases were viral meningitis (TB). Cerebrospinal fluid soluble interleukin 2 receptor (sIL-2R) levels were measured and compared with the control group measurements. Results The measured bits in children group were significantly higher than those in the control group. Among them, the group with tuberculous meningitis had the highest measured value, and there was a significant difference between each group (P <0.001). There was a partial overlap between the measured values of sIL-2R in the patients with TB and those with CNS. There is no overlap with the measured value of sick brain group. Conclusion The determination of sIL-2R in cerebrospinal fluid may be helpful in differentiating cerebral brain from brain and brain.