胃复安引起锥体外系症状的机理是什么?怎样防治?

• 出 处: 中国农村医学
• 发表日期: 1989年11期
• 关键词: 锥体外系症状 胃复安 多巴胺递质系统 不自主运动 纹状体 多巴胺受体 肌肉抽搐 肾功能不全 斜颈 共济失调

胃复安引起的锥体外系统反应,是由于它干扰了纹状体内多巴胺递质系统,阻断了多巴胺受体,导致该系统内乙酰胆碱的兴奋作用相对增强而出现肌张力变化,如肌肉抽搐、斜颈、共济失调、不自主运动等一系列锥体外系症状。胃复安引起的锥体外系症状发生率,一般与药物剂量大小、用药时间的长短呈正比,故应避免大剂量长期用药。肾功能不全者、孕妇、婴儿及精神病人慎

Metoclopramide induced extrapyramidal systemic response is due to it interferes with the dopamine neurotransmitter system in the striatum, blocking the dopamine receptor, resulting in the relative increase in the system of acetylcholine excitatory effects appear muscle tension changes, such as muscle twitching, Torticollis, ataxia, involuntary movement and a series of extrapyramidal symptoms. The incidence of extrapyramidal symptoms caused by metoclopramide is generally proportional to the size of the drug and the length of time it takes to administer it. Therefore, long-term administration of large doses should be avoided. Renal insufficiency, pregnant women, infants and mental patients cautious