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獐牙菜属植物Swertia chirayita在喜马拉雅山地区海拨1200～3050m处大量生长,由于其味苦,它的浸剂广泛被用作为助消化剂,驱虫剂和苦补剂,常取代法定的龙胆草制剂作退热剂用。作者在研究苦味植物降血糖作用时,观察到S. chirayita的95％乙醇提取物对大鼠有降血糖作用。生药的乙醇提取物进一步分离,发现其己烷部分在几种小鼠模型中有降血糖作用,血糖降低的最大值达27％。在Al-bino大鼠试验中,其降血糖作用呈剂量依赖关系,口服250mg/kg己烷提取物是最适剂量。因此用大量的大鼠试验模型,分离和鉴定上述具有剂量依赖的降血糖活性成分是值得的。
The Swertia chirayita Swampi grows abundantly in the Himalayas from 1,200 to 3,050 m. Because of its bitterness, its infusions are widely used as digestive aids, insect repellents and bitter tonics, often replacing the legal dragon. Bile grass preparations used as antipyretic agents. In the study of the hypoglycemic effect of bitter plants, the authors observed that the 95% ethanol extract of S. chirayita has a hypoglycemic effect on rats. The ethanol extract of the crude drug was further separated and its hexane moiety was found to have hypoglycemic effects in several mouse models, with a maximum blood glucose reduction of 27%. In the Al-bino rat test, its hypoglycemic effect was dose-dependent, 250mg/kg hexane extract was the optimal dose. Therefore, it is worthwhile to isolate and identify the above-mentioned dose-dependent hypoglycemic active ingredients using a large number of rat test models.