论文部分内容阅读
肝脏是维生素A的贮藏器官,对其在体内的正常分布、代谢转化有重要作用;同时,肝脏也是维生素A的靶器官。40多年前,人们就观察到肝病时常伴有维生素A代谢的异常。近10年来发现,维生素A可影响贮脂细胞产生胶原纤维,向成纤维细胞转化;大量服用维生素A类药物可导致多种形式的肝损害;乙醇可加重维生素A的肝毒性反应;缺乏维生素A与肝癌有关。因而,有关维生素A与肝病的关系越来越引起人们的关注。现就国外有关这方面的研究进展,综述如下。维生素A缺乏与肝病 1939年,Patek等在24名肝硬化患者中发现有19名伴有暗适应的异常,补充维生素A后
Liver is the storage organ of vitamin A, which plays an important role in its normal distribution and metabolism in the body. At the same time, the liver is also the target organ of vitamin A. More than 40 years ago, people often observed liver disease often accompanied by abnormal vitamin A metabolism. Over the past 10 years found that vitamin A can affect the storage of fat cells produce collagen fibers, transformed into fibroblasts; taking large amounts of vitamin A drugs can lead to various forms of liver damage; ethanol can aggravate the vitamin A hepatotoxic reactions; lack of vitamin A And liver cancer. Therefore, the relationship between vitamin A and liver disease has drawn more and more attention. Now on foreign research in this area, summarized as follows. Vitamin A Deficiency and Liver Diseases In 1939, Patek et al found 19 patients with dark-adapted abnormalities in 24 patients with cirrhosis. After vitamin A supplementation