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目的观察三维适形放疗(3D-CRT)同步化疗对局限期小细胞肺癌(LSCLC)的疗效及毒副反应。方法 69例LSCLC患者采用顺铂+足叶乙甙(PE)或卡铂+足叶乙甙(CE)方案化疗同步三维适形放疗,然后继续化疗,共4～6周期,观察疗效及毒副反应。结果完全缓解32例,总有效率为85.5%,1、2、3年总生存率分别为72%、35%、12%。全组未观察到4级急性和晚期副反应。结论 3D-CRT同步化疗用于LSCLC可获得满意的近、远期疗效,毒副反应小,有较高的临床可行性。
Objective To observe the curative effect and side effects of three-dimensional conformal radiotherapy (3D-CRT) simultaneous chemotherapy on small cell lung cancer (LSCLC). Methods Sixty-nine patients with LSCLC received synchronous three-dimensional conformal radiotherapy with cisplatin + etoposide (PE) or carboplatin + etoposide (CE), and then continued chemotherapy for 4-6 cycles to observe the curative effect and toxicity reaction. The results were completely relieved in 32 cases, the total effective rate was 85.5%, 1, 2, 3-year overall survival rates were 72%, 35%, 12%. No grade 4 acute and advanced side effects were observed in the whole group. Conclusions The 3D-CRT simultaneous chemosensitization can be used in LSCLC to obtain satisfactory short-term and long-term curative effects with less side effects and higher clinical feasibility.