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目的探讨米非司酮配伍米索前列醇治疗稽留流产的临床疗效。方法回顾性分析2010年4月至2011年9月应用米非司酮配伍米索前列醇治疗的稽留流产41例患者临床资料,并与同期使用己烯雌酚治疗的患者进行比较。结果治疗组放置米索前列醇24h内妊娠物自然排出36例,胚胎自然排出率87.8%;对照组清宫前妊娠组织自然排出5例,胚胎自然排出率12.2%;手术时间、术中出血量、人流综合征与再次清宫率均明显低于对照组,组间比较差异有统计学意义(P<0.05)。结论米非司酮配伍米索前列醇治疗稽留流产自然排出率高,术中出血少,手术时间短,再次清宫率及术中人流综合征发生率低,不良反应轻,临床应用安全、有效。
Objective To investigate the clinical efficacy of mifepristone combined with misoprostol in the treatment of missed abortion. Methods The clinical data of 41 patients with missed abortion treated with mifepristone and misoprostol between April 2010 and September 2011 were retrospectively analyzed and compared with those treated with diethylstilbestrol during the same period. Results In the treatment group, 36 cases were naturally excreted with misoprostol within 24 hours, and the natural rate of embryo excretion was 87.8%. In the control group, 5 cases were excreted spontaneously before pregnancy in the control group, and the spontaneous rate of embryo excretion was 12.2%. The operation time, intraoperative blood loss, The rates of abortion and recidivism were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). Conclusion The combination of mifepristone and misoprostol in the treatment of abortion spontaneous abortion rate, less bleeding, shorter operative time, rate of recanalization and intraoperative flow syndrome, low adverse reactions, clinical application of safe and effective.