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近日,一项刊登于国际杂志Nature Genetics上的研究报告中,来自美国洛杉矶希达-西奈(Cedars-Sinai)医学院的研究人员通过研究在食管肿瘤的组织样本中鉴别出了2000多个基因突变,从而详细阐述了癌症的复杂性,本文研究表明,单一肿瘤的不同区域或许具有多种遗传模式。该研究能够帮助解释为何靶向特殊遗传缺陷反而难以有效治疗癌症,对患者肿瘤进行单一活组织检查的外科医生仅能够解析部分肿瘤的特性和其遗传突变,此外,癌细胞还会不断改变其遗传组成。Dechen Lin博士表示,一个
In a recent study published in the international journal Nature Genetics, researchers from the Cedars-Sinai School of Medicine in Los Angeles identified more than 2,000 genetic mutations in tissue samples of esophageal tumors , Thus elaborating the complexity of the cancer, this study shows that different regions of a single tumor may have a variety of genetic patterns. The study can help explain why targeting specific genetic defects can not effectively treat cancer. Surgeons who single-biopsy their tumors can only analyze the characteristics of some tumors and their genetic mutations. In addition, cancer cells constantly change their inheritance composition. Dr. Dechen Lin said one