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以~(32)P—HBV DNA为探针,对50例具有一项以上乙肝血清免疫标志阳性病员及13例健康人白细胞DNA进行了研究。结果表明8例乙肝患者(16％)的白细胞存在游离形式的HBV DNA,6例(12％)患者的白细胞基因组有HBV DNA片段的整合。13例健康对照均无HBV DNA存在。 通过比较白细胞中存在的HBV DNA状态,相同于肝细胞内的HBV DNA,即既有HBV DNA整合片
Fifty cases of leukocyte DNA with one or more hepatitis B seropositive markers and 13 healthy controls were studied with ~ (32) P-HBV DNA as a probe. The results showed that free HBV DNA was present in 8 patients with hepatitis B (16%) and HBV DNA fragments in 6 patients (12%). No HBV DNA was detected in 13 healthy controls. By comparing the presence of HBV DNA in leukocytes, the same HBV DNA in the liver cells, ie both HBV DNA integration tablets