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[目的 ]探讨尿酸对重度妊娠高血压综合征围生儿结局的影响。 [方法 ]检测 6 8例重度妊高征患者及 31例正常妊娠妇女 (对照组 )血清尿酸、肌酐、尿素氮含量 ,比较其间统计学差异。 [结果 ]重度妊高征患者血清尿酸含量高于正常妊娠组 (P<0 .0 0 1) ,新生儿体重则低于正常对照组 (P<0 .0 5 ) ,围生儿死亡率高于对照组 (P<0 .0 1) ;在重度妊高征病例中 ,血清尿酸含量与新生儿体重、巨大儿发生率呈负相关 ,与低体重儿、围产儿死亡呈正相关。 [结论 ]血清尿酸含量与胎盘缺血、胎儿血供关系密切 ,可作为胎儿宫内环境恶化的较敏感指标 ,指导临床诊治
[Objective] To investigate the effect of uric acid on perinatal outcome in severe pregnancy-induced hypertension syndrome. [Methods] Serum levels of uric acid, creatinine and urea nitrogen were measured in 68 patients with severe PIH and 31 normal pregnant women (control group). The statistical differences were compared. [Result] The serum uric acid in patients with severe PIH was higher than that in normal pregnancy group (P0.01), while the weight of neonates was lower than that of normal control group (P0.05). The perinatal mortality rate was high In the control group (P <0.01), in patients with severe PIH, the level of serum uric acid was negatively correlated with the neonatal body weight and the incidence of macrosomia, and positively correlated with the death of low birth weight infants and perinatal infants. [Conclusion] Serum uric acid content is closely related to placental ischemia and fetal blood supply, which can be used as a sensitive index of fetal intrauterine environment deterioration to guide clinical diagnosis and treatment