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目的:探讨早期干预对先天性甲状腺功能低下儿童体格及智能发育的影响。方法:将80名先天性甲状腺功能低下患儿分为三组,常规治疗组只给予药物常规治疗,早期干预治疗组给予药物常规治疗、早期教育、早期干预和功能康复训练,非正规治疗组未按正规方法服用甲状腺功能低下药物或半年以后服用药物,无早期干预及功能康复训练。对所有患儿在14个月时进行体格检查及智能测验,包括身高、体重和头围的测量,婴幼儿智能发育检查量表(CDCC)评分。结果:与常规治疗组相比,早期干预治疗组患儿头围较高,差异有统计学意义,体重、身高稍高于常规治疗组,但差异无统计学意义。与非正规治疗组相比,早期干预治疗组患儿的体重、身高及头围均较高,差异有统计学意义。另外,智能测验方面,早期干预治疗组最高,非正规治疗组最低。结论:早期干预治疗可明显降低甲状腺功能低下患儿的体格及智力思维低下的发生率,提高生存质量。
Objective: To investigate the effect of early intervention on physical and mental development in children with congenital hypothyroidism. Methods: Eighty children with congenital hypothyroidism were divided into three groups. The conventional treatment group was given conventional treatment only. The early intervention treatment group was given conventional treatment, early education, early intervention and functional rehabilitation training. The non-formal treatment group According to the regular method of taking drugs with hypothyroidism or six months after taking drugs, no early intervention and functional rehabilitation training. Physical examination and intelligence tests were performed on all children at 14 months, including measurements of height, weight and head circumference, and CDCC scores. Results: Compared with the conventional treatment group, the head circumference of the early intervention group was higher, the difference was statistically significant, body weight and height slightly higher than the conventional treatment group, but the difference was not statistically significant. Compared with the non-canonical treatment group, the body weight, height and head circumference of the early intervention group were higher, the difference was statistically significant. In addition, the intelligence test, the highest early intervention group, the lowest informal treatment group. Conclusion: Early intervention can significantly reduce the incidence of hypoplasia and mental retardation in children with hypothyroidism and improve the quality of life.