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目的 :探讨肿瘤血管生长因子 (TAF)在原发性肝癌血清中的表达及其意义。方法 :对 184例临床确诊的原发性肝癌 (肝癌 )病人行 FAM方案肝动脉化疗栓塞术。应用生化比色定量法分别检测术前、术后血清 TAF的表达水平 ,并且与血清中甲胎蛋白 (AFP)表达、肿瘤大小、碘化油栓塞剂肿物充填量及其形态分布进行比较分析。结果 :全部病例 TAF术前、术后水平均高于正常水平 (P<0 .0 5 )。肝癌病人中仍有 30 .4% (5 6 / 184) AFP<2 0μg/ L,其术前、术后 TAF水平与 AFP阳性病例无显著性差异 (P>0 .0 5 ) ;TAF在介入术前后的下降程度与肿瘤的缩小幅度。碘化油充填肿瘤的大小及分布情况均有一定的相关性。结论 :血清 TAF表达结合 AFP检测及影像学检查可以早期发现原发性肝癌 ,减少漏诊率。并对肝癌的肿瘤瘤体情况、治疗疗效以及预后动态观察具有实用价值。
Objective: To investigate the expression of tumor angiogenic factor (TAF) in serum of primary hepatocellular carcinoma and its significance. Methods: 184 patients with clinically diagnosed primary liver cancer (HCC) underwent hepatic arterial chemoembolization with FAM regimen. The biochemical colorimetric method was used to detect the expression of TAF in preoperative and postoperative serums, and compared with the expression of AFP, the size of tumor, the amount and shape of tumor infiltrated with iodinated oil embolization agent . Results: The preoperative and postoperative TAF levels in all cases were higher than normal (P <0.05). There was still 30.4% (56/184) AFP <20μg / L in patients with hepatocellular carcinoma, there was no significant difference between preoperative and postoperative TAF levels and AFP positive cases (P> 0.05) Preoperative and postoperative decline and extent of tumor reduction. Iodized oil filled tumor size and distribution have some relevance. Conclusion: The combination of serum TAF expression with AFP detection and imaging can detect primary liver cancer early and reduce the rate of misdiagnosis. It also has practical value for the tumor of liver cancer, the curative effect and the dynamic observation of prognosis.