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目的：探讨联和检测组织金属蛋白酶ＭＭＰ－２、ＭＭＰ－９和ＭＭＰ－ＭＴ对胃癌细胞侵袭的诊断价值。方法：以胃癌患者癌组织（４１例），癌旁组织（１７例）为研究对象，采用免疫组化（ＳＰ）和分子原位杂交法检测ＭＭＰ－２、ＭＭＰ－９和ＭＭＰ－ＭＴ的表达。结果：胃癌组ＭＭＰ－２、ＭＭＰ－９和ＭＭＰ－ＭＴ表达与侵袭程度成正相关（Ｐ＜０．０５），而且胃癌组ＭＭＰｓ表达显著高于癌旁组织（Ｐ＜０．０５）。结论：一致性检验显示ＭＭＰｓ的免疫组化和原位杂交检测结果的关系密切相关（Ｐ＜０．０５），是胃癌侵袭转移检测较好的分子标志，可用于胃癌的预后判断
OBJECTIVE: To investigate the diagnostic value of MMP-2, MMP-9 and MMP-MT in the invasion of gastric cancer cells. METHODS: The expression of MMP-2, MMP-9 and MMP-MT was detected by immunohistochemistry (SP) and molecular in situ hybridization in gastric carcinoma (41 cases) and paracancerous tissues (17 cases). . Results: The expression of MMP-2, MMP-9, and MMP-MT in gastric cancer was positively correlated with the degree of invasion (P<0.05), and the expression of MMPs in gastric cancer was significantly higher than that in adjacent tissues (P<0.05). Conclusion: The consistency test showed that the relationship between MMPs immunohistochemistry and in situ hybridization results is closely related (P<0.05). It is a good molecular marker for invasion and metastasis detection of gastric cancer and can be used for the prognosis of gastric cancer.