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目的 :探讨中西医结合治疗原发性肾病综合征 (PNS)临床意义。方法 :2 6 6例PNS患者随机分为治疗组 (中药 +强的松 )和对照组 (强的松 ) ,观察两组治疗前后的临床表现 ,2 4h尿蛋白定量、血浆白蛋白、血脂、肾功能及尿纤维蛋白降解产物 (FDP) ,副作用和并发症及复发情况。结果 :治疗前两组各项生化指标 ,尿FDP均明显异常 ,治疗后治疗组各项生化指标及尿FDP明显改善 ,治疗前后比较 (P <0 .0 1或 <0 .0 5 )。治疗组总有效率 (97.2 % )高于对照组 (72 .2 % ) ,对照组副作用和并发症发生率 (5 9.5 % )高于治疗组 (2 1.8% ) ,治疗组复发率 (2 .8% )低于对照组(13.5 % )。结论 :中西医结合治疗具有调节PNS免疫紊乱的作用。能提高疗效 ,减少副作用和并发症。对预防感染 ,巩固疗效 ,减少复发有一定帮助。
Objective: To explore the clinical significance of integrated traditional Chinese and western medicine in the treatment of primary nephrotic syndrome (PNS). Methods: Twenty-six patients with PNS were randomly divided into treatment group (Chinese medicine + prednisone) and control group (prednisone). The clinical manifestations, 24 h urinary protein, serum albumin, serum lipids, Renal function and urinary fibrin degradation products (FDP), side effects and complications and recurrence. Results: The biochemical indexes and urinary FDP in the two groups before treatment were obviously abnormal. The biochemical indexes and urinary FDP in the treatment group were significantly improved after treatment, before and after treatment (P <0.01 or <0.05). The total effective rate (97.2%) in the treatment group was higher than that in the control group (72.2%). The incidence of side effects and complications in the control group (9.55%) was higher than that in the treatment group (21.8% 8%) lower than the control group (13.5%). Conclusion: The combination of traditional Chinese and Western medicine has the effect of regulating PNS immune disorder. Can improve the efficacy and reduce side effects and complications. To prevent infection, consolidate the curative effect, reduce the relapse to have a certain help.