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目的观察香菇多糖腹腔灌注治疗晚期肝癌腹水的临床效果。方法63例晚期肝癌腹水患者随机分为治疗组33例与对照组30例。治疗组放腹水后腹腔灌注香菇多糖(4~6 mg次/,5~7 d 1次,共4~6次为1个疗程),同时给予对症支持治疗。对照组定时放腹水,仅行对症支持治疗。每2周复查1次腹部B超,进行疗效评价。结果治疗组33例腹水控制有效率达39.39%(CR 2例,PR 11例);对照组30例,有效率10.00%(PR 3例)。2组有效率差异有统计学意义(P<0.05)。治疗后2组KPS评分分别为71.00±8.73、58.00±10.52,差异有统计学意义(P<0.05)。结论香菇多糖腹腔灌注对晚期肝癌腹水有一定疗效,并可以改善其生活质量。
Objective To observe the clinical efficacy of lentinan injection in the treatment of advanced liver cancer ascites. Methods Sixty-three patients with advanced hepatocellular carcinoma were randomly divided into treatment group (n = 33) and control group (n = 30). In the treatment group, the ascites was infused with lentinan (4 ~ 6 mg times per day, once every 5 ~ 7 days, 4 ~ 6 times as a course), and symptomatic supportive treatment was given. Control group ascites fluid, only symptomatic supportive treatment. A review of the abdomen every 2 weeks B ultrasound, the efficacy evaluation. Results The effective rate of ascites control in the treatment group was 39.39% (CR 2 cases, PR 11 cases). In the control group, the effective rate was 10.00% (PR 3 cases). The difference between the two groups was statistically significant (P <0.05). The KPS scores of the two groups after treatment were 71.00 ± 8.73 and 58.00 ± 10.52, respectively, with significant difference (P <0.05). Conclusion Lentinus edodes polysaccharide peritoneal perfusion of advanced liver cancer has a certain effect, and can improve their quality of life.