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目的观察日本血吸虫所致肝纤维化患者经有效病原学治疗后，肝纤维化的转归。方法对３７９例经粪孵确诊的病例采用超声检测评价肝脏纤维化程度，从中随机抽取５０例作为对照组，３２９例作为实验组，实验组给予首次吡喹酮 ４０ｍｇ／ｋｇ顿服普治，并于每年６月及 １２月两次复查，阳性者１２月进行复治，连续治疗３年，对照组在首次及每年１２月均给予安慰剂治疗。超声检测于每年６月及１２月各检测１次。治疗及超声检测均采用双盲法。结果实验组Ⅰ级肝损害病例增加，治疗后第３０个月，出现了０级病例，Ⅲ级损害的比例出现逐年下降的趋势。对照组病情则呈现稳定不变或略有加重的趋势。两组病例肝纤维化转变的趋势经多元Ｌｏｇｉｓｔｉｃ回归分析，表明在控制时间因子的条件下，实验组下降趋势与对照组比较有显著性意义（ｔ＝４． ３８，Ｐ＜０． ０１）。结论日本血吸虫所致肝纤维化经过有效的病原治疗后，纤维化程度可得到明显的改善，３０个月后，轻度纤维化病例可恢复正常。
Objective To observe the outcome of hepatic fibrosis after effective pathogenic treatment of schistosoma japonicum induced liver fibrosis in patients. Methods A total of 379 cases diagnosed by fecal hatching were evaluated with ultrasound to evaluate the degree of liver fibrosis. Fifty cases were randomly selected as the control group and 329 cases as the experimental group. The experimental group received the first praziquantel 40 mg / In June and December each review twice, positive in December for retreatment, continuous treatment for 3 years, the control group were given placebo in the first and each December. Ultrasound testing in June and December each test 1. Treatment and ultrasound testing are double-blind method. Results In the experimental group, grade Ⅰ liver damage was increased in the experimental group. At the 30th month after the treatment, grade 0 occurred. The grade Ⅲ lesion showed a decreasing trend year by year. The control group showed a stable or slightly aggravating trend. The trend of liver fibrosis in both groups was analyzed by multivariate logistic regression analysis. The results showed that in the control of time factor, the declining tendency in the experimental group was significant compared with the control group (t = 4.38, P <0.01). Conclusion After hepatic fibrosis caused by Schistosoma japonicum, the degree of fibrosis can be significantly improved after effective pathogen treatment. After 30 months, mild fibrosis can return to normal.