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目的探讨C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)的急性加重期临床价值。方法检测慢性阻塞性肺疾病的急性加重期细菌感染的86名患者人院后第l、3d及出院前1dCRP,WBC,ESR,同时观察日体温和咳嗽频率、程度、痰颜色,同时给予抗生素治疗,并比较治疗前后这些指标的变化情况。结果 C反应蛋白在患者入院时的阳性率为100%,明显高于其他常规指标,在治疗后,CRP在常规检测指标还未有显著变化时已经明显下降,并与临床的症状相一致,其治疗前后的差异具有统计学意义(P<0.01)。结论 CRP在COPD急性加重期是一个良好的观察指标,可反映抗生素的即时疗效,比WBC,ESR更快速且敏感。
Objective To investigate the clinical value of C-reactive protein (CRP) in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Eighty-six patients with bacterial infection in acute exacerbation stage of chronic obstructive pulmonary disease were detected on day 1, day 3 and pre-discharge 1-day CRP, WBC and ESR. The body temperature and cough frequency, extent and sputum color were also observed. Antibiotic treatment , And compare these indicators before and after treatment changes. Results The positive rate of C-reactive protein at admission was 100%, which was obviously higher than other routine indexes. After treatment, CRP had obviously decreased when the routine test indexes had not changed significantly and was consistent with the clinical symptoms The difference between before and after treatment was statistically significant (P <0.01). Conclusion CRP is a good indicator of acute exacerbation of COPD, reflecting the immediate effect of antibiotics, which is faster and more sensitive than WBC and ESR.