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目的 :探究试论二黄新伤止痛凝胶膏剂与软膏剂体外透皮特性及其差异性。方法 :在本次研究中采用Franz扩散池进行体外透试验,以蛇床子素含量为衡量和评价指标,对二黄新伤止痛凝胶膏剂与软膏剂的吸收特性和差异性进行分析。结果 :在本次研究中,在2h-12h内的每个时间点的指标系数都存在一定的差异性,二黄新伤止痛凝胶膏剂与二黄新伤止痛软膏两者的累积透皮量和累积透皮率的P值均小于0.05,其中二黄新伤止痛凝胶膏剂的透皮特性明显优于二黄新伤止痛软膏,各项数据差异性显著。结论 :二黄新伤止痛凝胶膏剂的透皮性明显优于软膏剂,其不良反应比较少,操作更方便,值得临床推广和应用。
Objective: To explore the in vitro transdermal properties and differences of two yellow hurts analgesic gel ointment and ointment. Methods: Franz diffusion cells were used in this study to conduct in vitro penetration tests. Taking osthole content as a measure and evaluation index, the absorption characteristics and differences of two yellow hurts analgesic gel ointment and ointment were analyzed. Results: In this study, there was a certain difference in the indicator coefficients at each time point between 2h and 12h. The cumulative transdermal volume of Erhuang Xinqi analgesic gel and Erhuang Xinbing analgesic ointment And the cumulative transdermal rate of P values were less than 0.05, of which two Huang new injury analgesic gel transdermal patch was significantly better than Erhuang Xin injury analgesic ointment, the data significant difference. Conclusion: The permeability of Erhuang Xinjiao analgesic gel ointment is obviously better than that of ointment. The adverse reaction is less and the operation is more convenient, which is worthy of clinical promotion and application.