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[目的]探讨大肠腺癌组织中环氧合酶-2（COX-2）和组织蛋白酶D的表达及意义。[方法]采用免疫组织化学法检测62例大肠粘液腺癌标本及31例癌旁正常黏膜组织中COX-2和组织蛋白酶D的表达，分析其临床意义。[结果]大肠腺癌组织中COX-2和组织蛋白酶D的表达率分别为75．8％和82．3％，显著高于正常黏膜中的12．9％和22．6％，其差异有统计学意义（ P ＜0．01）；COX-2和组织蛋白酶D阳性表达与肿瘤大小及分化程度无关（ P ＞0．05），与浸润深度、淋巴结转移、Dukes分期呈正相关。[结论]在大肠癌恶变进程中，COX-2和组织蛋白酶D表达发生相应变化，其可能参与了大肠癌发生、发展的过程，两者联合检测可为临床判断大肠腺癌的恶性生物学行为提供参考。“,”[Objective] To explore the expression of cyclooxygenase-2(COX-2) and cathepsin D in large in-testinal adenocarcinoma and their significance .[Methods]immunohistochemical method was used to detect the expression of COX-2 and cathepsin D in 62 specimens of large intestinal mucinous adenocarcinoma and 31 nor-mal mucous tissue adjacent to the cancer .Clinical significance was analyzed .[Results]The expression rates of COX-2 and cathepsin D in large intestinal adenocarcinoma were 75 .8% and 82 .3% respectively ,which were markedly higher than those in normal mucosa(12 .9% and 22 .6% ) ,and there was significant difference( P0 .05) ,but positively correlated with the depth of invasion ,lymph node metastasis and Dukes staging .[Conclusion] The expression of COX-2 and cathepsin D has the corresponding changes in the progression of large intestinal canceration ,which may participate in the occurrence and development of colon cancer .The de-tection of COX-2 combined with cathepsin D can provide the reference for assessing malignant biological behav-ior of large intestinal adenocarcinoma .