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目的:分析胎儿药源性疾病与孕妇不合理用药的相关性,为避免胎儿药源性疾病的发生提供参考。方法:通过调查问卷、病历调查的方式收集临床不合理用药孕妇的用药情况、胎儿发育情况及新生儿健康状况,评价不合理用药与胎儿药源性疾病的相关性。结果:孕妇在怀孕期间服用庆大霉素、依托红霉素、利巴韦林、绒促性素、丙基硫氧嘧啶、维生素B6、维生素D、维生素C、诺氟沙星、磺胺药、吲哚美辛和乙酰水杨酸盐均能引起胎儿药源性疾病,且其与用药时间过早、时长过久和剂量过大成正相关(P<0.05)。结论:胎儿药源性疾病与孕妇的不合理用药有一定的相关性,故孕妇应在医生指导下合理用药,以确保胎儿的身体健康。
Objective: To analyze the correlation between fetal drug-induced diseases and irrational drug use in pregnant women and to provide reference for avoiding the occurrence of drug-induced fetal diseases. Methods: Through investigating questionnaires and medical records, we collected the medication, fetal development and neonatal health status of unreasonable pregnant women, and evaluated the relationship between irrational drug use and fetal drug-induced diseases. Results: Pregnant women took gentamicin during pregnancy, relying on erythromycin, ribavirin, velvet hormone, propylthiouracil, vitamin B6, vitamin D, vitamin C, norfloxacin, sulfonamides, Both indomethacin and acetylsalicylic acid could cause drug-induced diseases in fetuses. And it was positively related to the premature drug administration, prolonged time and over-dose (P <0.05). Conclusion: Drug-related diseases of fetus have some correlation with irrational use of pregnant women. Therefore, pregnant women should be given proper medication under the guidance of doctors to ensure their health.