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临床研究证明,心绞痛发作时,冠状循环有前列腺素和血栓素释放。扩张血管性前列隙素(PG),即PGE_2和PGI_2(前列环素),可防止缺血性损害,有益于冠状循环和心肌。相反,强效缩血管剂PGF_(2α)和血栓素A_2(TXA_2)则有害。实验和临床资料说明,前列腺素与血栓素平衡紊乱,在急性心肌梗塞发病机理中占有重要作用。
Clinical studies have shown that angina pectoris, coronary prostaglandin and thromboxane release. Dilated vascular prostatants (PG), PGE 2 and PGI 2 (prostacyclin), prevent ischemic damage and contribute to coronary circulation and myocardium. In contrast, potent vasoconstrictors PGF 2α and TXA 2 are detrimental. Experimental and clinical data show that prostaglandin and thromboxane imbalance in the pathogenesis of acute myocardial infarction plays an important role.