论文部分内容阅读
目的：观察睾酮、雌二醇对去势大鼠肠道碘吸收速率的影响。方法：成年Ｗｉｓｔａｒ大鼠，雌雄各５０只，分别随机分为５组，其中四组切除睾丸或卵巢，另一组为假手术组，手术后７天，肌注不同剂量的丙酸睾丸素（雄鼠）或己烯雌酚（雌鼠）三天；采用原位肠道灌流技术，观察其空、回肠碘吸收速率。灌流结束后，留血清测定ＴＳＨ、Ｔ４和睾酮或雌二醇。结果：去势雄鼠空、回肠Ｋ１２值降低，Ｋ２１值升高，Ｋ０２值降低，慢速相生物半减期（ＳＰ１／２）延长，表明其对碘的吸收能力降低。去势雌鼠空肠Ｋ１２值升高，Ｋ２１降低，Ｋ０２值增加，ＳＰ１／２缩短，说明其吸收碘的能力增强。雌雄大鼠甲状腺激素水平均未见明显变化。结论：在生理状况下睾酮对肠道碘吸收有促进作用，雌二醇则呈抑制效应。提示性激素对肠道碘吸收有影响，这可能是造成甲状腺肿发生率存在性别差异的原因之
Objective: To observe the effects of testosterone and estradiol on intestinal iodine uptake rate in ovariectomized rats. Methods: Adult Wistar rats, 50 male and 50 female, were randomly divided into five groups, including four groups of testis or ovaries, and the other group of sham operation group. Seven days after operation, different doses of testosterone propionate Male rats) or diethylstilbestrol (females) for three days; using in situ intestinal perfusion technique to observe the empty, ileum iodine absorption rate. After the perfusion was completed, the serum was taken for determination of TSH, T4 and testosterone or estradiol. Results: K12 value and K21 value of empty and ileum of castrated male rats decreased, K02 value decreased, and half-life of slow-phase animals (SP1 / 2) prolonged, indicating that their absorption capacity of iodine decreased. Ovarieal jejunum K12 value increased, K21 decreased, K02 value increased, SP1 / 2 shortened, indicating its ability to absorb iodine increased. Thyroid hormone levels in both male and female rats showed no significant changes. CONCLUSION: Testosterone promotes intestinal iodine absorption under physiological conditions and estradiol inhibits it. Prompt sex hormones on the intestinal absorption of iodine, which may be the cause of the sex differences in the incidence of goiter