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本文用５－羟色胺（５－ＨＴ）抗血清的免疫组织化学方法对大鼠回肠（外纵肌全层铺片标本）内含５－ＨＴ免疫反应性（５－ＨＴ－ＩＲ）神经元进行了观察研究。正常大鼠回肠壁内神经节（丛）内可见少数５－ＨＴ－ＩＲ核周体，及肠肌丛周围和节间束中含有丰富的５－ＨＴ－ＩＲ纤维。５－羟色胺酸（５－ＨＴＰ）处理后大鼠与正常鼠相比较，回肠壁丛内５－ＨＴ－ＩＲ胞体和带膨体纤维的可见数稍多，及免疫反应性增强。本研究对大鼠回肠内在的５－ＨＴ能神经元的存在提供了直接的形态学证据，并初步讨论了肠５－ＨＴ能神经元对胃肠运动的调节功能及其可能的受体机理。
In this study, 5-HT-immunoreactive (5-HT-IR) neurons in the ileum of the rat (full longitudinal lay of external longitudinal muscle) were subjected to immunohistochemistry with 5-HT antiserum Observational study. A small number of 5-HT-IR perinuclear bodies were observed in the ileal wall ganglion in normal rats, and the 5-HT-IR fibers were abundant in the peri-intestinal and internode bundles. Compared with normal rats, the number of 5-HT-IR somatic cells and expanded fibers in ileal wall plexus were slightly increased and the immunoreactivity increased after treatment with 5-HTP. This study provided direct morphological evidence for the presence of 5-HT neurons in the ileum of rats and initially discussed the regulation of gastrointestinal motility by intestinal 5-HT neurons and their possible receptor mechanisms.