论文部分内容阅读
本文报道10例肾病综合征患者的维生素D代谢。10例中9例作过肾活检:3例为增殖性肾小球肾炎,3例为膜性增殖性肾小球肾炎,1例为膜性肾小球肾炎,2例为微小改变性肾小球肾炎。10例均有浮肿、大量蛋白尿、低白蛋白血症和低钙血症,血清硷性磷酸酶均升高,除2例血清肌酐较高外,余均正常。10例病人血清25-羟胆骨化醇均显著地低于对照组,血浆维生素D结合球蛋白(V D B G)也显著地低于对照者均值。所有肾病病人尿中均检出V D B G,而对照者尿中未检出。有3例肾病病人和2例对照者给予口服~3H标记的胆骨化醇,深入进行了研究。3例病人服入~3H-胆骨化醇后,尿中迅即出现标记维生素,主
This article reports 10 cases of nephrotic syndrome in patients with vitamin D metabolism. Nine of 10 patients underwent renal biopsy: 3 were proliferative glomerulonephritis, 3 were membranoproliferative glomerulonephritis, 1 was membranous glomerulonephritis and 2 were microscopic changes in the kidneys Ball nephritis. All 10 cases had edema, a large amount of proteinuria, hypoalbuminemia and hypocalcemia, serum alkaline phosphatase were elevated, except for 2 cases of high serum creatinine, the rest were normal. Serum 25-hydroxycholecalciferol in 10 patients was significantly lower than the control group, and plasma vitamin D-binding globulin (V D B G) was also significantly lower than the control mean. V D B G was detected in urine of all patients with kidney disease, whereas urine of controls was not detected. Three patients with nephropathy and two controls were given orally administered ~ 3H labeled cholecalciferol for further study. 3 patients taking ~ 3H - cholecalciferol, the urine immediately marked with vitamins, the main