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目的探讨癌基因蛋白p53、C-erbB-2（p185）过度表达与粘液表皮样癌生物学行为的关系。方法利用微波免疫组织化学方法对32例人粘液表皮样癌的癌基因蛋白p53、C-erbB-2进行检测。结果正常诞腺组织p53、C-erbB-2均为阴性反应。癌旁导管上皮细胞两者阳性率分别为10.0％及15.0％，但腺泡细胞阴性。粘波表皮样癌组织中p53、C-erbB-2阳性率分别为40.6％及46.9％。p53、C-erbB-2在粘液细胞、表皮样细胞及中间细胞内均有表达。p53、C-erbB-2的表达与粘液表皮样癌肿瘤组织学类型、分化程度及肿瘤复发等肿瘤生物学行为密切相关（P＜0.01）。结论p53、C-erbB-2可作为粘液表皮样癌的分化性标志物，用于监测病情、判断预后等。
Objective To investigate the relationship between overexpression of oncogene protein p53, C-erbB-2 (p185) and biological behavior of mucoepidermoid carcinoma. Methods The oncogene proteins p53 and C-erbB-2 in 32 human mucoepidermoid carcinoma were detected by microwave immunohistochemistry. Results Normal gland tissue p53, C-erbB-2 were negative. The positive rates of both para-carcinoma and ductal epithelial cells were 10.0% and 15.0%, respectively, but the acinar cells were negative. The positive rates of p53 and C-erbB-2 in the viscoelastic epidermoid carcinoma were 40.6% and 46.9% respectively. p53, C-erbB-2 in mucus cells, epidermal cells and intermediate cells are expressed. The expressions of p53 and C-erbB-2 were closely related to the tumor histological types, differentiation degree and tumor recurrence in mucoepidermoid carcinoma (P <0.01). Conclusions p53 and C-erbB-2 can be used as markers of differentiation of mucoepidermoid carcinoma for monitoring the disease and prognosis.