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目的:观察阿霉素(adriblastina,ADR)造成大鼠心室功能不同程度损害时,心肌内血管紧张素Ⅱ(Ang Ⅱ)等的改变及培哚普利对其影响。方法:给大鼠腹腔注射ADR 1 mg/kg,5天1次,依累计量分为A(3次)、B(5次)及C(8次)3组,D组仅注射生理盐水;培哚普利干预组则分别于注射2(A组)、4(B组)及6次(C组)后开始于饮水中喂培哚普利(1 mg·kg~(-1)/日)。于停给ADR第10天麻醉下测心功能,留取动脉血及心肌标本用放射免疫法测Ang Ⅱ等。每小组动物均为7只。结果:ADR造成心功能轻中度损害时,血浆Ang Ⅱ和醛固酮已显著升高,与对照组比较,P均<01.1,而心肌中Ang Ⅱ的增高较缓。当心功能进一步损害时,心肌Ang Ⅱ进一步升高,而血浆Ang Ⅱ不再增加。培哚普利可明显遏制心肌和血浆Ang Ⅱ的增加(与ADR组比较,P均<0.05),心室功能损害亦较轻;当ADR剂量继续增加和延长使用后,改善心室功能的作用略有减弱。结论:培哚普利对大鼠能明显阻抑ADR引起心肌Ang Ⅱ的增高并减轻对心功能的损害。
OBJECTIVE: To observe the change of myocardial angiotensin Ⅱ (Ang Ⅱ) and the effect of perindopril in rats with different degrees of ventricular dysfunction induced by adriblastina (ADR). Methods: The rats were injected intraperitoneally with 1 mg / kg of ADR once a day for 5 days and divided into three groups according to the cumulative dose: group B (5 times) and group C (8 times) Perindopril intervention group began to drink water perindopril (1 mg · kg -1 / day) after injection of 2 (group A), 4 (group B) and 6 times (group C) ). Cardiac function was measured under anesthesia on day 10 of ADR, and arterial blood and myocardial samples were collected for radioimmunoassay. Each group of animals are 7. Results: When mild or moderate impairment of cardiac function was caused by ADR, the plasma Ang Ⅱ and aldosterone levels were significantly increased, P <0.01 compared with the control group, while the increase of Ang Ⅱ in myocardium was slower. Attention further damage to function, myocardial Ang Ⅱ increased further, while plasma Ang Ⅱ no longer increased. Perindopril could significantly inhibit the increase of Ang Ⅱ in myocardium and plasma (all P <0.05 compared with ADR group), and mild ventricular dysfunction. When ADR dose continued to increase and prolong use, the effect of improving ventricular function was slight Weakened. Conclusion: Perindopril can obviously inhibit the increase of myocardial Ang Ⅱ induced by ADR and reduce the damage of cardiac function in rats.