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目的探讨沧州地区农村不同类型毛细支气管炎(简称毛支)后反复喘息患儿潮气呼吸肺功能变化及临床意义。方法选取3岁以下沧州地区农村毛支后反复喘息患儿102例为研究对象,依据哮喘预测指数分为阳性组45例和阴性组57例。另选30例健康婴幼儿为对照组。分阶段于喘息发作急性期、缓解期和恢复期(喘息缓解3个月后)对两组患儿进行潮气呼吸肺功能检测,比较参数达峰时间比TPTEF/TE和达峰容积比VPEF/VE的变化,并与健康对照组对比。结果在喘息急性期阳性组、阴性组的TPTEF/TE、VPEF/V、VT、Ti、Te差异均无统计学意义(P>0.05),但与对照组比较,两组患儿TPTEF/TE、VPEF/V均明显降低(P<0.01)。在缓解期阳性组、阴性组的TPTEF/TE、VPEF/VE比急性期均升高,仍低于对照组,且阴性组高于阳性组,差异均有统计学意义(P<0.05)。在恢复期阳性组的TPTEF/TE、VPEF/VE较缓解期升高,但仍明显低于对照组,差异有统计学意义(P<0.01),而阴性组与对照组差异已无统计学意义(P>0.05)。结论沧州地区农村毛细支气管炎后反复喘息患儿,阳性组喘息缓解3个月后仍持续存在肺功能损害,较阴性组肺功能损害持续时间长,恢复慢,潮气呼吸肺功能检测可为早期识别哮喘并制定规范的治疗方案防治哮喘的发生提供一些临床参考。
Objective To investigate the changes of pulmonary function and its clinical significance in children with recurrent wheezing after different types of bronchiolitis (CBC) in rural areas of Cangzhou. Methods A total of 102 children with recurrent wheezing after rural branch of Cangzhou were selected as study subjects under the age of 3 years old. According to asthma predictive index, 45 cases were divided into positive group and 57 negative cases. Another 30 healthy infants as the control group. The respiratory function of the two groups were detected in the acute stage, the remission stage and the convalescence stage (3 months after respite). The peak time of the comparison parameters was higher than that between TPTEF / TE and peak volume ratio VPEF / VE The changes were compared with healthy controls. Results There was no significant difference in TPTEF / TE, VPEF / V, VT, Ti and Te between the acute positive group and the negative group (P> 0.05), but compared with the control group, TPTEF / TE, VPEF / V were significantly lower (P <0.01). The TPTEF / TE and VPEF / VE in the positive group and the negative group were higher than those in the acute phase, and still lower than those in the control group (P <0.05). The TPTEF / TE and VPEF / VE in the recovery group were higher than those in the remission group, but still significantly lower than those in the control group (P <0.01), while there was no significant difference between the negative group and the control group (P> 0.05). Conclusions Children with recurrent wheezing after rural bronchi- bronchitis in Cangzhou still have persistent lung dysfunction 3 months after remission. The duration of lung dysfunction is longer than that in the negative group, and recovery is slow. Early detection of pulmonary function can be detected early Asthma and to develop standardized treatment programs to prevent the occurrence of asthma provide some clinical reference.