论文部分内容阅读
本文报道一种能有效摄取汞化合物的不溶性螯合微球。由于微球具有巨大表面积、低毒性和对汞化物很强的亲合力等优点,故有希望成为一种新的口服高效解毒剂。该微球是由多醇化合物构成,文中对微球的制备的及其对汞化合物的结合试验均作了详细报道。螯合微球的总表面积很大。其对汞的摄取速率比同重量的微球凝聚体大得多。微球在较大的pH范围内(pH2.0～pH8.5)都可较好地与有机或无机汞化合物结合。但对碱土和碱金属离子(如Na~+,Mg~(++),Ca~(++)等)却无摄取作用。除此以外,微球还具有竞争性摄取与白蛋白和半胱氨酸结合的汞化合物的良好能力。与对汞有较好亲合力的商品树脂(亚氨二乙酸酯,Srafion
This article reports an insoluble chelating microsphere capable of efficiently uptake of mercury compounds. Due to their large surface area, low toxicity and strong affinity for mercury compounds, microspheres hope to become a new oral antidote. The microspheres are composed of polyol compounds. The preparation of microspheres and their binding experiments with mercury compounds are all reported in detail. The total surface area of chelated microspheres is large. It has a much greater mercury uptake than the same weight of microsphere aggregates. Microspheres can bind well to organic or inorganic mercury compounds over a wide pH range (pH 2.0 to pH 8.5). However, there is no uptake of alkaline earth and alkali metal ions (such as Na ~ +, Mg ~ (++), Ca ~ (++), etc.). In addition, microspheres also have the ability to compete with mercury compounds that bind albumin and cysteine. Commercial resins with good affinity for mercury (iminodiacetate, Srafion