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摘要目的探讨表观扩散系数(ADC)作为一种生物指标在评价上尿路尿路上皮癌(UUT-UCC)侵袭性中的作用。方法连续36个非转移性疾病行肾输尿管切除术的病人参加了这项前瞻性研究,ADC与临床变量相比,包括Ki-67标记指数(LI)和癌症特异性生存率(CSS)。结果总的3年CSS率为82%(中位随访36个月)。ADC在3级病变显著低于1-2级(P=0.011),与Ki-67(ρ=-0.59,P=0.000 2)呈显著负相关。低的ADC(<1.10×10-3mm2/s)和较短的CSS(P=0.039)显著相
Abstract Objective To investigate the role of apparent diffusion coefficient (ADC) as a biomarker in evaluating the invasiveness of upper urinary tract urothelial carcinoma (UUT-UCC). METHODS: Thirty-six consecutive patients undergoing nephroureterectomy for non-metastatic disease were enrolled in this prospective study. ADCs included Ki-67 labeling index (LI) and cancer-specific survival (CSS) compared with clinical variables. Results The overall 3-year CSS rate was 82% (median follow-up 36 months). ADC was significantly lower than Grade 1-2 in Grade 3 (P = 0.011) and negatively correlated with Ki-67 (P = -0.59, P = 0.0002). Low ADC (<1.10 × 10-3 mm2 / s) and shorter CSS (p = 0.039) significant phase