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报告40例肾病综合征患儿的尿蛋白选择性。患儿年龄为1～13岁。男31例,女9例。单纯型18例,肾炎型22例。以醋酸纤维薄膜电泳判断尿蛋白选择性。选择性蛋白尿者21例,非选择性蛋白尿者19例。单纯型者72.2％(13/18)为选择性蛋白尿,肾炎型者36.4％(8/22)为选择性蛋白尿,二者差异显著(P<0.05)。选择性蛋白尿者激素治疗效果明显优于非选择性蛋白尿者(P<0.02)。尿蛋白选择性预测肾病综合征患儿激素治疗反应的敏感性为66.7％、特异性为76.9％。作者认为,醋酸纤维薄膜电泳法判断的尿蛋白选择性,可作为预测肾病综合征患儿激素治疗反应的无创伤性生化指标。
Urinary protein selectivities in 40 children with nephrotic syndrome were reported. Children aged 1 to 13 years old. 31 males and 9 females. 18 cases of simple type, 22 cases of nephritis. Acetate membrane electrophoresis to determine urinary protein selectivity. Selective proteinuria in 21 cases, 19 cases of non-selective proteinuria. The simple type of 72.2% (13/18) of patients with selective proteinuria, nephritis, 36.4% (8/22) of the selective proteinuria, the difference was significant (P <0.05). Selective proteinuria hormone therapy was significantly better than non-selective proteinuria (P <0.02). Urinary protein selective prediction of nephrotic syndrome in children with hormone therapy response sensitivity was 66.7%, specificity was 76.9%. The authors believe that the selectivity of urinary protein as judged by the cellulose acetate membrane electrophoresis can be used as a noninvasive biochemical indicator of hormone response in children with nephrotic syndrome.