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目的 探讨Rb蛋白与胆囊癌的肿瘤生物学行为的关系。方法 采用免疫组化SP染色方法检测 41例胆囊癌、7例胆囊腺瘤及 14例胆囊炎石蜡标本Rb蛋白表达水平。结果 Rb蛋白表达阳性率在胆囊癌组为 5 8.7% ,明显低于胆囊炎 ( 10 0 % )及胆囊腺瘤组 ( 10 0 % ) ;且低分化癌组与高、中分化癌组 ,S4 、S5期与S1、S2 及S3 期比较均有显著性差异 (P <0 .0 5 )。结论 Rb蛋白表达与胆囊癌的分化程度、浸润深度及预后密切相关
Objective To investigate the relationship between Rb protein and tumor biological behavior of gallbladder cancer. Methods Immunohistochemical SP staining was used to detect the expression of Rb protein in 41 cases of gallbladder carcinoma, 7 cases of gallbladder adenoma and 14 cases of cholecystitis. Results The positive rate of Rb protein was 57.7% in gallbladder carcinoma group, significantly lower than that in cholecystitis (100%) and gallbladder adenoma group (10.0%). , There was a significant difference between S5 and S1, S2 and S3 (P <0.05). Conclusion The expression of Rb protein is closely related to the differentiation, depth of invasion and prognosis of gallbladder carcinoma