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目的 探讨自体外周血造血干细胞 (APBSCT)治疗系统性红斑狼疮 (SLE)的临床效果。方法 采集经用环磷酰胺 (CTX) 2 0 0 0mg/m2 静脉注射和粒细胞集落刺激因子 (G CSF) 2 5 0 μg/d皮下注射动员后的外周血造血干细胞 ,预处理用CTX 4 8mg·kg-1·d-1,连续静脉滴注 3d ,回输干细胞后用抗胸腺细胞球蛋白 (ATG) 13 5mg/kg ,体内去T细胞 ,分 3d静脉滴注 ,用G CSF刺激升高白细胞 ,观察APBSCT前后免疫指标与临床表现。结果 APBSCT后患者的临床表现基本消失 ,免疫指标正常 ,抗体转阴。结论 APBSCT治疗SLE有较好的疗效 ,远期疗效还需长期随访观察。
Objective To investigate the clinical effect of autologous peripheral blood stem cell (APBSCT) on systemic lupus erythematosus (SLE). Methods Peripheral blood hematopoietic stem cells were collected from subcutaneous injection of 250 μg / d CTX 2000 mg / m 2 intravenous injection and granulocyte colony-stimulating factor (G CSF). Pretreated with CTX 48 mg Kg · d-1 · d-1 for three days. After the stem cells were transfused, the T cells were treated with anti-thymocyte globulin (ATG) 13 5mg / kg, Leukocytes, observed before and after APBSCT immune indicators and clinical manifestations. Results The clinical manifestations of patients after APBSCT disappeared, the immune index was normal and the antibody turned negative. Conclusion APBSCT has a good curative effect on SLE, long-term follow-up is still required.