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[目的]探讨2型糖尿病合并大血管病变患者同型半胱氨酸水平及相关因素。[方法]173例2型糖尿病患者,其中合并大血管病变83例,未合并大血管病变90例,健康体检人群80例作为正常对照组。测定血浆同型半胱氨酸、血清叶酸、VB12、全血谷胱甘肽还原酶活性系数、空腹血糖、血脂及肾功水平。以血浆同型半胱氨酸为因变量,进行Pearsan相关分析。[结果]合并大血管病变组血浆同型半胱氨酸高于未合并组(P﹤0.01);2型糖尿病患者血浆同型半胱氨酸高于正常对照组(P﹤0.01);同型半胱氨酸水平与病程、叶酸、全血谷胱甘肽还原酶活性系数、载脂蛋白A、肌酐存在相关关系;病程、低密度脂蛋白为2型糖尿病高同型半胱氨酸血症的危险因素,而VB12、核黄素、高密度脂蛋白为保护因素。[结论]2型糖尿病合并大血管病变患者血浆同型半胱氨酸水平升高,且与叶酸、核黄素、载脂蛋白A、肌酐、病程存在相关关系。
[Objective] To investigate the level of homocysteine in type 2 diabetic patients with macrovascular complications and related factors. [Methods] A total of 173 patients with type 2 diabetes mellitus, including 83 cases of macrovascular complications, 90 cases of non-complicated macrovascular diseases and 80 cases of healthy people as normal control group. Plasma homocysteine, serum folate, VB12, whole blood glutathione reductase activity coefficient, fasting blood glucose, blood lipid and renal function were measured. Plasma homocysteine as a dependent variable, Pearsan correlation analysis. [Results] Plasma homocysteine in patients with macrovascular complications was significantly higher than that in patients without macroinvasions (P <0.01), plasma homocysteine in patients with type 2 diabetes was significantly higher than that in controls (P <0.01), homocysteine Acid level and duration of disease, folic acid, whole blood glutathione reductase activity coefficient, apolipoprotein A, creatinine exist correlation; duration, low density lipoprotein is type 2 diabetes hyperhomocysteinemia risk factors, The VB12, riboflavin, high-density lipoprotein as a protective factor. [Conclusion] Plasma homocysteine level is elevated in patients with type 2 diabetes mellitus and macroangiopathy, and there is a relationship between the levels of plasma homocysteine and folic acid, riboflavin, apolipoprotein A and creatinine.