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以警告信号加足底电击的方式 (简称信号电击 )对不同年龄、性别和种类小鼠进行应激 ,每天 2 4min ,共 7d。结果发现 ,应激后免疫器官退化 ,重量减轻 ,而且这种变化与年龄和性别有关。胸腺退化 ,年龄大的鼠比年龄小的鼠更明显 ,而脾脏则相反 ,年龄小的鼠更敏感。另外 ,胸腺的退化雄性要高于雌性 ,而脾脏则没有性别上的差异。从种类上看 ,Swiss鼠比Balb/c鼠更敏感。对淋巴结来说 ,这种退化没有表现出年龄、性别和种类的差异。此外 ,应激使胸腺、脾脏内的淋巴细胞总数和骨髓内淋巴细胞的比例减少。这一结果说明 ,胸腺和脾脏的退化 ,不是由于组织内体液的减少 ,而是胸腺和脾脏内淋巴细胞绝对数减少之故。
The warning signal plus foot shock (referred to as signal shock) on different age, gender and type of mouse stress, 24 4min, a total of 7d. The results showed that the immune organs after stress degenerated, weight loss, and this change with age and gender. Thymus degeneration, older rats than younger mice more obvious, while the spleen is the opposite, younger mice more sensitive. In addition, the degenerative thymus is higher in males than in females, while the spleens have no gender differences. Swiss rats are more sensitive than Balb / c mice by type. For lymph nodes, this degeneration did not show age, gender and type of differences. In addition, stress reduces the total number of lymphocytes in the thymus and spleen and the proportion of lymphocytes in the bone marrow. This result suggests that the degeneration of the thymus and spleen is not due to the reduction of body fluids in the tissues but to the reduction of the absolute number of lymphocytes in the thymus and spleen.