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目的探讨处理过期流产的更为安全、有效和简便的方法。方法选择200例闭经3个月以下的过期流产的病例随机分为两组。观察组100例米非司酮150mg顿服,次日晨米索前列醇600mg口服,8h后或出血多即清宫。对照组100例,乙烯雌酚3mg,3次/d口服7d后或出血多时即清宫,观察两组孕囊排出率、出血量、手术时间、未清宫、二次清宫、出血时间、生殖器感染、按时来经、经量改变、痛经、闭经率。结果观察组孕囊排出率85%,出血量(8.12±2.51)ml,手术时间(3.22±1.45)min,未清宫35%、二次清宫无、出血时间(5.03±1.22)d,生殖器感染5%按时来经85%、经量改变23%、痛经5%、闭经率2%。对照组孕囊排出率9%、出血量(50.03±3.25)ml,手术时间(17.36±1.56)min,未清宫无、二次清宫37%出血时间(13.52±1.53)d,生殖器感染36%按时来经31%、经量改变82%、痛经29%、闭经率18%。观察组明显优于对照组。结论米非司酮配伍米索前列醇作为过期流产清宫术前准备,比乙烯雌酚更为安全、有效和简便。
Objective To explore a safer, more effective and easier way to deal with abortion. Methods A total of 200 cases of overdue abortion under 3 months after amenorrhea were randomly divided into two groups. Observation group of 100 patients with mifepristone 150mg Dayton, misoprostol 600mg orally the next day, 8h or more after the bleeding that is clear Palace. The control group of 100 patients, diethylstilbestrol 3mg, 3 times / d orally 7d or bleeding after a long time that the Qing Gong, observe the two groups of gestational sac discharge, bleeding, surgery time, did not clear the palace, the second curettage, bleeding time, genital infections, Time to by the amount of change, dysmenorrhea, amenorrhea rate. Results The rate of gestational sac excretion was 85%, the amount of bleeding (8.12 ± 2.51) ml, the operation time (3.22 ± 1.45) min, the unexplicit palace 35%, the second stage without curettage, the bleeding time (5.03 ± 1.22) d and the genital infection 5 % By time to 85%, by 23% change in volume, dysmenorrhea 5%, amenorrhea rate of 2%. In the control group, the gestational sac drainage rate was 9%, the amount of bleeding (50.03 ± 3.25) ml, the operation time (17.36 ± 1.56) min, the uterus without curettage, the 37% bleeding time after the second curettage (13.52 ± 1.53) d and the genital infection 36% Come through 31%, by volume change 82%, dysmenorrhea 29%, amenorrhea rate 18%. Observation group was significantly better than the control group. Conclusions Mifepristone and misoprostol are safe, effective and simple as diethylstilbestrol for preoperative abortion.