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Lisinopril是一种血管紧张素转换酶的抑制剂。作者观察了该药对13例不同病因肾脏病患者血压、尿蛋白和肾血流动力的影响,并与传统的降压药治疗进行了比较。结果显示,两种疗法都能使血压明显降低。只有在用lisinopril治疗12周后,血压才显著地低于传统治疗。lisinopril使尿蛋白减少61±40％,而传统疗法对尿蛋白排泄无明显影响。用lisinoprnil治疗的头8周中,血压的降低相当于传统治疗,但尿蛋白却较传统治疗明显减少。
Lisinopril is an angiotensin-converting enzyme inhibitor. The authors observed the effects of this drug on blood pressure, urinary protein and renal hemodynamics in 13 patients with different etiologies of renal disease and compared them to the traditional antihypertensive drugs. The results showed that both treatments significantly reduced blood pressure. Only after 12 weeks of treatment with lisinopril was blood pressure significantly lower than the traditional treatment. Lisinopril reduced urinary protein by 61 ± 40%, whereas traditional therapy had no significant effect on urinary protein excretion. In the first 8 weeks of treatment with lisinoprnil, the reduction in blood pressure was equivalent to that of conventional treatment, but urinary protein was significantly reduced compared to conventional treatment.