论文部分内容阅读
作者探讨消炎痛(INDO)对造血组织的辐射防护作用及其机理.方法:1.小鼠(雌性,C3Hf/kam,3月龄)受250kV的X线全身照射6.6～8.9Gy,剂量率为1.7Gy/min,分别测定INDO组(照前饮用35μg/ml INDO溶液6天)与对照组的LD50/30)2.小鼠X线照射6.5～9.5Gy,分INDO组(照前或照后饮用INDO溶液1～6天)与对照组,照前30min均腹腔注射WR-2721(400mg/kg),照后第9天测定内源脾结节数;3.INDO组(饮用INDO溶液6天)与对照组小鼠各照射1.5、2、3、4、5及6Gy,照后立即制备双侧股骨骨髓细胞悬液,以2×10~4～2.8×10~6的细胞数静脉注射给受8.5Gy照后1天的小鼠,注射后8天测定外源脾结节数.结果:1.INDO组与对照组内源脾结节数均随
The authors explored the radioprotective effects of indomethacin (INDO) on hematopoietic tissues and their mechanisms. Methods: 1. Mice (female, C3Hf/kam, 3 months old) were exposed to 250kV X-rays with a total body dose of 6.6 to 8.9 Gy. At 1.7 Gy/min, the INDO group (drinking 35 μg/ml INDO solution for 6 days before drinking) and the LD50/30 of the control group were weighed. 2. The X-ray irradiation of the mice was 6.5-9.5 Gy, divided into INDO groups (before or after irradiation). Drink INDO solution for 1 to 6 days) and control group, WR-2721 (400mg/kg) was injected intraperitoneally 30min before irradiation, and endogenous spleen nodules were measured on the 9th day after irradiation; 3. INDO group (drinking INDO solution for 6 days The mice in the control group were irradiated with 1.5, 2, 3, 4, 5, and 6 Gy each. Immediately after irradiation, bilateral femoral bone marrow cell suspensions were prepared and intravenously administered at a cell count of 2×10 4 to 2.8×10-6. The number of exogenous spleen nodules was determined 8 days after the injection of 8.5 Gy of the mice 1 day after irradiation. Results: 1. The number of endogenous spleen nodules in both INDO and control groups