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目的比较分析河北省脊髓灰质炎(脊灰)疫苗预防接种的安全性。方法收集河北省2015年5-10月三价脊灰减毒活疫苗(tOPV)、脊灰灭活疫苗(IPV)和2016年同期二价脊灰减毒活疫苗(bOPV)、IPV的疑似预防接种异常反应(AEFI)监测数据,比较分析各疫苗AEFI报告发生率。结果河北省2015年5-10月tOPV、IPV的AEFI报告发生率分别为5.64/10万、35.96/10万;2016年同期bOPV、IPV的AEFI报告发生率分别为16.06/10万、17.85/10万。各疫苗AEFI均以≤1岁年龄组、一般反应为主,主要发生在接种疫苗后≤48h。结论河北省各脊灰疫苗预防接种安全性良好,bOPV的AEFI报告发生率高于tOPV,需进一步加强脊灰疫苗安全性监测。
Objective To compare the safety of vaccination against poliomyelitis (polio) in Hebei Province. Methods Trivalent poliovirus live vaccine (tOPV), poliovirus inactivated vaccine (IPV) and bivalent poliovirus live vaccine (bOPV) in Hebei province from May to October in 2015 were collected, and the suspected prevention of IPV Inoculation abnormal response (AEFI) monitoring data, comparative analysis of the incidence of AEFI report of each vaccine. Results The incidence of AEFI in tOPV and IPV from May to October in 2015 in Hebei Province was 5.64 / 100 000 and 35.96 / 100 000 respectively. The incidence of AEFI in bOPV and IPV in 2016 was 16.06 / 100 000 and 17.85 / 10 respectively Million Each vaccine AEFI ≤ 1 year age group, the general response, mainly occurred after vaccination ≤ 48h. Conclusion The polio vaccine vaccination in Hebei Province is safe and the incidence of AEFI in bOPV is higher than that of tOPV. The surveillance of poliovirus safety should be further strengthened.