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目的探讨老年高血压患者颈动脉内膜中层厚度(IMT)与血清同型半胱氨酸(Hcy)、胱抑素C(Cys-C)等的关系。方法测定80例(IMT增厚组)及77例(IMT正常组)老年高血压患者空腹静脉血Hcy、Cys-C、肌酐、尿酸等水平。结果 IMT增厚组Hcy为(24.0±8.3)μmol/L、Cys-C(2.4±0.7)pg/ml、肌酐(104.0±31.1)μmol/L、尿酸(356.8±110.8)μmol/L;均显著高于IMT正常对照组。血清Hcy水平与肌酐、尿素氮、尿酸呈显著的正相关;Hcy、Cys-C是影响老年高血压患者颈动脉IMT增厚的危险因素。结论联合检测血清Hcy、Cys-C水平有助于评价老年高血压患者大血管动脉粥样硬化的进展程度。
Objective To investigate the relationship between carotid intima-media thickness (IMT), serum homocysteine (Hcy) and cystatin C (Cys-C) in elderly hypertensive patients. Methods Fasting venous blood Hcy, Cys-C, creatinine and uric acid were measured in 80 patients with IMT thickening group and 77 patients with IMT normal group. Results Hcy was (24.0 ± 8.3) μmol / L, Cys-C (2.4 ± 0.7) pg / ml and creatinine were (104.0 ± 31.1) μmol / L and 356.8 ± 110.8 μmol / L respectively Higher than IMT normal control group. Serum Hcy levels were positively correlated with creatinine, urea nitrogen and uric acid; Hcy and Cys-C were the risk factors of carotid IMT thickening in elderly patients with hypertension. Conclusions The combined detection of serum Hcy and Cys-C levels can be helpful to evaluate the progression of macrovascular atherosclerosis in elderly patients with hypertension.