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目的 :了解HBV感染者血清可溶性细胞粘附分子 -1、肿瘤坏死因子α和白细胞介素 -6水平与肝细胞损伤的关系。方法 :以ELISA法检测慢性乙型肝炎、肝硬化、慢性无症状HBV携带者和正常人血清可溶性细胞粘附分子 -1、肿瘤坏死因子α、白细胞介素 -6水平 ,并比较血清ALT变化。结果 :慢性乙型肝炎患者和肝硬化患者血清可溶性细胞粘附分子 -1、肿瘤坏死因子α、白细胞介素 -6水平升高 ,并与ALT升高成正比 ,而正常人和慢性无症状HBV携带者表现正常。结论 :可溶性细胞粘附分子 -1、肿瘤坏死因子α、白细胞介素 -6与HBV感染的肝细胞损伤相关
Objective: To investigate the relationship between the levels of serum soluble cell adhesion molecule-1, tumor necrosis factor-α and interleukin-6 in hepatocytes in patients with HBV infection. Methods: Serum levels of soluble cell adhesion molecule - 1, tumor necrosis factor - α, interleukin - 6 in patients with chronic hepatitis B, cirrhosis, chronic asymptomatic HBV carriers and normal persons were detected by ELISA. The changes of serum ALT were compared. Results: Serum levels of soluble cell adhesion molecule-1, tumor necrosis factor-α and interleukin-6 were elevated in patients with chronic hepatitis B and cirrhosis, and were positively correlated with the elevation of ALT. However, in normal subjects and patients with chronic asymptomatic HBV Carrier performance is normal. Conclusion: Soluble cell adhesion molecule - 1, tumor necrosis factor - α, interleukin - 6 are associated with hepatocellular injury in HBV infection