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目的探讨缺血性脑血管病患者血清一氧化氮（ＮＯ）水平变化及其与氧自由基的关系。方法检测２２例短暂性脑缺血发作（ＴＩＡ）、３７例脑梗塞、４２例脑动脉硬化患者血清ＮＯ及超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）水平，并与３０例健康人对照分析。结果与健康对照组比较，ＴＩＡ组血清ＮＯ水平呈显著性升高（Ｐ＜０．０１），脑梗塞组无明显变化，脑动脉硬化组则有显著性降低（Ｐ＜０．０１）；与脑动脉硬化组比较，脑梗塞组血清ＮＯ水平呈显著性升高（Ｐ＜０．０１）；各患者组血清ＳＯＤ水平均显著低于健康对照组，而ＭＤＡ含量则显著高于健康对照组（Ｐ＜０．０１）。结论在缺血性脑损伤发展过程中，ＮＯ起重要作用，并与氧自由基存在一定的相互关系，尚需进一步研究。目的探讨缺血性脑血管病患者血清一氧化氮（ＮＯ）水平变化及其与氧自由基的关系。方法检测２２例短暂性脑缺血发作（ＴＩＡ）、３７例脑梗塞、４２例脑动脉硬化患者血清ＮＯ及超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）水平，并与３０例健康人对照分析。结果与健康对照组比较，ＴＩＡ组血清ＮＯ水平呈显著性升高（Ｐ＜０．０１），脑梗塞组无明显变化，脑动脉硬化组则有显著性降低（Ｐ＜０．０１）；与脑动脉硬化组比较，?
Objective To investigate the changes of serum nitric oxide (NO) and its relationship with oxygen free radicals in patients with ischemic cerebrovascular disease. Methods Twenty-two patients with transient ischemic attack (TIA), 37 cerebral infarctions and 42 patients with cerebral arteriosclerosis were enrolled in the study. Serum NO, SOD and MDA levels were measured and compared with 30 healthy controls Human control analysis. Results Compared with the healthy control group, serum NO levels in TIA group were significantly increased (P <0.01), no significant changes in cerebral infarction group, but significantly decreased in cerebral arteriosclerosis group (P <0.01) The level of serum NO in cerebral infarction group was significantly higher than that in cerebral arteriosclerosis group (P <0.01). The level of serum SOD in each group was significantly lower than that in healthy control group, but MDA level was significantly higher than that in healthy control group P <0.01). Conclusion NO plays an important role in the development of ischemic brain injury and has a certain relationship with oxygen free radicals. However, further study is needed. Objective To investigate the changes of serum nitric oxide (NO) and its relationship with oxygen free radicals in patients with ischemic cerebrovascular disease. Methods Twenty-two patients with transient ischemic attack (TIA), 37 cerebral infarctions and 42 patients with cerebral arteriosclerosis were enrolled in the study. Serum NO, SOD and MDA levels were measured and compared with 30 healthy controls Human control analysis. Results Compared with the healthy control group, serum NO levels in TIA group were significantly increased (P <0.01), no significant changes in cerebral infarction group, but significantly decreased in cerebral arteriosclerosis group (P <0.01) Cerebral arteriosclerosis group,?