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曾有人提出,防腐剂可能被固体药物所吸附而引起失效。英国副药典收载的磺胺二甲嘧啶(简称SM_2)合剂的腐败可能是因为所含苯甲酸被混悬的SM_2吸附所致。作者研究了SM_2对苯甲酸的吸附作用以及聚乙烯吡咯酮(简称PVP)、甲基纤维素、羧甲基纤维素钠对此作用的抑制效应。当苯甲酸的初始浓度为100毫克/100毫升,SM_2浓度0.3克/100毫升直到10克/100毫升时,有94%的苯甲酸被吸附,即0.1克SM_2大约要吸附34毫克苯甲酸。SM_2浓度
It has been suggested that preservatives may be caused by the adsorption of solid drugs cause failure. The corruption of sulfamethazine (abbreviated as SM_2) contained in the British Pharmacopoeia can be attributed to the adsorption of benzoic acid onto suspended SM_2. The authors studied the adsorption of benzoic acid SM_2 and polyvinylpyrrolidone (PVP), methyl cellulose, sodium carboxymethyl cellulose on the inhibition of this effect. When the initial concentration of benzoic acid was 100 mg / 100 ml and the concentration of SM 2 was 0.3 g / 100 ml up to 10 g / 100 ml, 94% of benzoic acid was adsorbed, that is, about 0.1 g SM_2 adsorbed approximately 34 mg of benzoic acid. SM_2 concentration