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目的 探讨肝细胞癌患者经根治性切除后的主要预后影响因素。方法 对 5 6例经根治性切除的患者进行回顾性统计 ,应用 Cox比例风险模型对可能影响预后的 16项指标进行了多因素分析 ,并建立生存预测方程。结果 总生存率 1,3,5年分别为89.73% ,5 4.0 8% ,2 9.12 % ,中位生存期 78.2 4月。影响肝癌预后最明显的因素是门脉癌栓、C- myc表达及肿瘤包膜。生存预测方程总χ2 =5 3.2 81,P<0 .0 0 1。按预后指数分组 ,低危组、中危组及高危组间 5年生存率具显著差异 ,P<0 .0 5。结论 肝细胞癌预后由多种因素决定 ,对于低危组及中危组患者 ,仍应积极手术治疗以期获得较好疗效。
Objective To investigate the main prognostic factors of patients with hepatocellular carcinoma after radical resection. Methods A total of 56 patients undergoing radical resection were retrospectively analyzed. Cox proportional hazards model was used to analyze the multivariate analysis of 16 factors that may influence prognosis, and the survival prediction equation was established. Results The overall survival rate was 89.73%, 5 4.08%, and 2.9.1% respectively in 1, 3 and 5 years. The median survival time was 78.2 April. The most obvious factors affecting the prognosis of HCC are portal thrombus, C-myc expression and tumor capsule. The survival prediction equation is χ2=5 3.2 81, P<0. 0 0 1. According to the prognostic index, there was a significant difference in the 5-year survival rate between the low-risk group, the intermediate-risk group, and the high-risk group, P<0.05. Conclusion The prognosis of hepatocellular carcinoma is determined by many factors. For the low-risk group and the intermediate-risk group, active surgical treatment should be performed to obtain better results.